Our lab is branching out. This fall we cross the Baltic sea and set up a new lab in Umeå, Sweden - at the Laboratory for Molecular Infection Medicine Sweden, MIMS. Do you like ribosomes? Do you also think that is ppGpp the main G nucleotide in bacteria? Are you stringent enough? Do you know somebody who fits the bill?
If yes, then good news are that we have two PhD and one postdoctoral positions up for grabs. Drop me a line at vasili.hauryliuk@molbiol.umu.se!
So it is finally out: the cryoEM structure of Tet(O) on the ribosome we have collaborated on with Joachim Frank's lab is finally published on in Nature Communications. Tet(O) is a bacterial translational GTPase that clears the ribosome from tetracycline antibiotic, and structural data provided in the paper shed light on the mechanism of Tet(O)-mediated resistance. Recently cryoEM of Tet(O)'s close relative, Tet(M) was published by Beckmann and Wilson labs, so now one can compare the two. And yes, they look very similar. No surprise there.
References:
Li et al. Nature Communications (2013) PIMD: 23403578
Dönhöfer at al. PNAS (2012) PIMD: 23027944
A very nice scheme of the ppGpp biosynthesis pathways can be found on the MetaCyc (1). Seems to be a very useful database in general.
References:
Caspi et al. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. NAR 2012 Jan;40(Database issue):D742-53 PIMD: 22102576
