I am reading loads of yeast genetics papers recently, and I wonder... Imagine yeast getting sapient, and starting doing science. Genetics, in particular. On humans, actually.
For instance they could do some screens for temperature-sensitive mutants (huge, massive saunas in action). Imagine the figures in the papers to go along with this sort of experiments. Some allele crossing experiments in search of synthetic lethality - that would be great as well. With photos of F0 and F1. Auxotrophic humans with plasmids complementing their deficiency as useful tools - complementation experiments will be particularly cruel - no complementation - well, tough luck!
I am really glad yeast are rather silly and not very proactive.