Thursday, February 14, 2013

Tet(O) cryoEM structure is out!

So it is finally out: the cryoEM structure of Tet(O) on the ribosome we have collaborated on with Joachim Frank's lab is finally published on in Nature Communications. Tet(O) is a bacterial translational GTPase that clears the ribosome from tetracycline antibiotic, and structural data provided in the paper shed light on the mechanism of Tet(O)-mediated resistance. Recently cryoEM of Tet(O)'s close relative, Tet(M) was published by Beckmann and Wilson labs, so now one can compare the two. And yes, they look very similar. No surprise there.

References:

Li et al. Nature Communications (2013) PIMD: 23403578

Dönhöfer at al. PNAS (2012) PIMD:  23027944


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